Researcher Dr. Robert Eoff has received a $1.2 million grant from the National Science Foundation to continue his work at the University of Arkansas for Medical Sciences (UAMS) on DNA damage, cell replication and its implications for diseases like dementia, ALS and cancer. Eoff is an associate professor in the Department of Biochemistry and Molecular Biology in the UAMS College of Medicine and a member of UAMS’ Winthrop P. Rockefeller Cancer Institute. Dr. Julie Gunderson, assistant professor of physics at Hendrix College in Conway, is collaborating with Eoff on the project. The four-year grant will also support graduate student training at UAMS and undergraduate trainees at Hendrix. Eoff’s research team studies what happens when DNA damage is not repaired in a timely manner and ends up blocking the mechanics behind how copies of new cells are made. Specifically, he studies the effect of large amounts of guanine in DNA sequences,…

Researcher Dr. Robert Eoff has obtained a $1.2 million grant from the Nationwide Science Basis to continue his work on the University of Arkansas for Medical Sciences (UAMS) on DNA wound, cell replication and its implications for ailments esteem dementia, ALS and most cancers.

Eoff is an accomplice professor in the Department of Biochemistry and Molecular Biology in the UAMS School of Medication and a member of UAMS’ Winthrop P. Rockefeller Most cancers Institute. Dr. Julie Gunderson, assistant professor of physics at Hendrix School in Conway, is collaborating with Eoff on the project. The four-year grant will furthermore serve graduate pupil coaching at UAMS and undergraduate trainees at Hendrix.

Eoff’s be taught team be taught what happens when DNA wound is now not repaired in a well timed manner and ends up blocking the mechanics in the again of how copies of unique cells are made. Particularly, he be taught the assemble of large portions of guanine in DNA sequences, that could perchance also assemble abnormal structures called G-quadruplexes (G4).

“Imagine making an strive to duplicate a doc containing over six billion letters in the span of some hours,” Eoff mentioned. “Now imagine discovering that the text contains many phrases esteem ‘Mississippi,’ ‘Czechoslovakia,’ ‘Oberschleissheim’ and ‘Solgohachia.’ Even whereas you’re on a tight agenda, that you should perchance want to gradual down somewhat whereas you happen to achieve to those tricky phrases. Because it turns out, here’s potentially a correct analogy for what happens when enzymes enthusiastic by DNA replication stumble upon certain sequences that dangle an abundance of guanine bases.”

Errors in these G4 sequences can lead to adjustments in the genome that are linked with human disease. Shall we embrace, neurological ailments such as frontotemporal dementia, amyotrophic lateral sclerosis (ALS), and the intellectual incapacity fragile X syndrome have all been linked to dysfunctional G4 repairs.

There would possibly perchance be furthermore a substantive and rising physique of literature linking G4 to the biology of most cancers and most cancers therapies. Many most cancers-linked genes are managed by G4 motifs, and chromosomes in tumor specimens are inclined to be broken more continuously advance G4 web sites than other DNA sequences.

However, scientists enact now not fully stamp how these errors occur.

For this particular grant, Eoff will glimpse the characteristic of a a vogue of enzyme called Rev1 in copying G4 sequences. Rev1 is a DNA polymerase — an enzyme that catalyzes synthesis of unique strands of DNA.

“Successful completion of this be taught will give us the next working out of how G4 replication errors occur and how they could also have attain about in the first situation,” Eoff mentioned. “Expectantly, this can give us unique insight into replication barriers, which reason a wide vary of issues in humans and other species, as a predominant step in direction of striking this bigger working out to spend in the assemble of unique therapies and therapies.”

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